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Prophylaxis of gout attack during initiation of therapy with allopurinol and uricosuric drugs:

Digestiveabdominal crampingabdominal paindiarrhealactose intolerancenauseavomiting.

The treatment duration should be decided after factors such as flare frequencygout duration and the presence and size of tophi have been assessed.

Colchicine has a narrow therapeutic windowThe administration should be discontinued if toxic symptoms such as nauseavomitingabdominal paindiarrhoea occur.

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25 mg kg 10- methoxy – 3 h colchicine was administered i.