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Assessment of the carcinogenic potential of selegiline in mice and rats is ongoing for all dosage formsSelegiline did not induce mutations or chromosomal damage when tested in the bacterial mutation assay in Salmonella typhimurium and in an in vivo chromosomal aberration assayWhile these studies provide some reassurance that selegiline is not mutagenic or clastogenicthey are not definitive because of methodological limitationsNo definitive in vitro chromosomal aberration or in vitro mammalian gene mutation assays have been performed.

Selegiline should also not be used with other drugs which are also monoamine oxidase inhibitorse.glinezolid.

The occurrence of stupormuscular rigiditysevere agitationand elevated temperature has been reported in some patients receiving the combination of selegiline and meperidineSymptoms usually resolve over days when the combination is discontinuedThis is typical of the interaction of meperidine and MAOIsOther serious reactionsincluding severe agitationhallucinationsand deathhave been reported in patients receiving this combinationsee CONTRAINDICATIONSSevere toxicity has also been reported in patients receiving the combination of tricyclic antidepressants and ELDEPRYL and selective serotonin re-uptake inhibitors and ELDEPRYLSee WARNINGS for detailsOne case of hypertensive crisis has been reported in a patient taking the recommended doses of selegiline and a sympathomimetic medicationephedrine

This medication may interfere with certain medical/laboratory testsincluding brain scan for Parkinson’s diseasepossibly causing false test resultsMake sure laboratory personnel and all your doctors know you use this drug.

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