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This drug may rarely cause seriouspossibly fatal liver diseaseIf you notice any of the following rare but very seriousside effectsstop taking mefenamic acid and consult your doctor or pharmacist right awaypersistent nausea/vomitingsevere stomach/abdominal painweaknessdark urineyellowing eyes/skin.

What is the most important information I should know about mefenamic acidPonstel

Advise patients to be alert for the symptoms of cardiovascular thrombotic eventsincluding chest painshortness of breathweaknessor slurring of speechand to report any of these symptoms to their healthcare provider immediatelysee WARNINGSCardiovascular Thrombotic Events

If you take mefenamic acid for a long period of timeyour doctor may want to check you on a regular basis to make sure this medication is not causing harmful effectsDo not miss any scheduled visits to your doctor.

Elevations of ALT or ASTthree or more times the upper limit of normalULNhave been reported in approximately 1of NSAID-treated patients in clinical trialsIn additionraresometimes fatalcases of severe hepatic injuryincluding fulminant hepatitisliver necrosisand hepatic failure have been reported.

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ponstel cannot be used in patients with known hypersensitivity to mefenamic acid, for the treatment of perioperative pain in the setting of coronary artery bypass graft cabg surgery, asthma, urticaria, active ulceration or chronic inflammation of gastrointestinal tract.