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RespiratoryAsthmanasal stuffinessrespiratory depressionpotentially fataland apneapotentially fatalSee WARNINGS-Respiratory Depression

Promethazine should not be used in children younger than 2 years because it may cause seriouspossibly fatalslow/shallow breathingWhen using this medication in children 2 years and olderthe lowest effective dosage should be usedand other drugs that affect breathing should be avoidedGet medical help right away if slow/shallow breathing occurs.

Since promethazine HCI administered intravenouslyby injectioncan cause severe chemical irritation and damage to tissuesdeep intramuscular injectiona technique administering medication deep into the musclesis the preferred method of injectionPromethazine hydrochloride injections should not be given by intra-arterialwithin an arteryinjectionunder any circumstancesdue to the risk of severe arteriospasmspasm in an arteryand resulting gangrene.

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keep promethazine with codeine oral solution and all medicines out of the reach of children.